22 research outputs found
Accelerated expansion from ghost-free bigravity: a statistical analysis with improved generality
We study the background cosmology of the ghost-free, bimetric theory of
gravity. We perform an extensive statistical analysis of the model using both
frequentist and Bayesian frameworks and employ the constraints on the expansion
history of the Universe from the observations of supernovae, the cosmic
microwave background and the large scale structure to estimate the model's
parameters and test the goodness of the fits. We explore the parameter space of
the model with nested sampling to find the best-fit chi-square, obtain the
Bayesian evidence, and compute the marginalized posteriors and mean
likelihoods. We mainly focus on a class of sub-models with no explicit
cosmological constant (or vacuum energy) term to assess the ability of the
theory to dynamically cause a late-time accelerated expansion. The model
behaves as standard gravity without a cosmological constant at early times,
with an emergent extra contribution to the energy density that converges to a
cosmological constant in the far future. The model can in most cases yield very
good fits and is in perfect agreement with the data. This is because many
points in the parameter space of the model exist that give rise to
time-evolution equations that are effectively very similar to those of the
CDM. This similarity makes the model compatible with observations as
in the CDM case, at least at the background level. Even though our
results indicate a slightly better fit for the CDM concordance model
in terms of the -value and evidence, none of the models is statistically
preferred to the other. However, the parameters of the bigravity model are in
general degenerate. A similar but perturbative analysis of the model as well as
more data will be required to break the degeneracies and constrain the
parameters, in case the model will still be viable compared to the
CDM.Comment: 42 pages, 9 figures; typos corrected in equations (2.12), (2.13),
(3.7), (3.8) and (3.9); more discussions added (footnotes 5, 8, 10 and 13)
and abstract, sections 4.2, 4.3 and 5 (conclusions) modified in response to
referee's comments; references added; acknowledgements modified; all results
completely unchanged; matches version accepted for publication in JHE
A Profile Likelihood Analysis of the Constrained MSSM with Genetic Algorithms
The Constrained Minimal Supersymmetric Standard Model (CMSSM) is one of the
simplest and most widely-studied supersymmetric extensions to the standard
model of particle physics. Nevertheless, current data do not sufficiently
constrain the model parameters in a way completely independent of priors,
statistical measures and scanning techniques. We present a new technique for
scanning supersymmetric parameter spaces, optimised for frequentist profile
likelihood analyses and based on Genetic Algorithms. We apply this technique to
the CMSSM, taking into account existing collider and cosmological data in our
global fit. We compare our method to the MultiNest algorithm, an efficient
Bayesian technique, paying particular attention to the best-fit points and
implications for particle masses at the LHC and dark matter searches. Our
global best-fit point lies in the focus point region. We find many
high-likelihood points in both the stau co-annihilation and focus point
regions, including a previously neglected section of the co-annihilation region
at large m_0. We show that there are many high-likelihood points in the CMSSM
parameter space commonly missed by existing scanning techniques, especially at
high masses. This has a significant influence on the derived confidence regions
for parameters and observables, and can dramatically change the entire
statistical inference of such scans.Comment: 47 pages, 8 figures; Fig. 8, Table 7 and more discussions added to
Sec. 3.4.2 in response to referee's comments; accepted for publication in
JHE
Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines
The purpose of this work was to analyze chemokine and chemokine receptor expression in untreated and in irradiated squamous cell carcinoma of the head and neck (SCCHN) tumor cell lines, aiming at the establishment of assays to test for the relevance of chemokine and chemokine receptor expression in the response of SCCHN to radiotherapy and radiochemotherapy. Five low passage and 10 established SCCHN lines, as well as two normal cell lines, were irradiated at 2Â Gy or sham-irradiated, and harvested between 1 and 48Â h after treatment. For chemokines with CC and CXC structural motifs and their receptors, transcript levels of target and reference genes were quantified relatively by real-time PCR. In addition, CXCL1 and CXCL12 protein expression was analyzed by ELISA. A substantial variation in chemokine and chemokine receptor expression between SCCHN was detected. Practically, all cell lines expressed CCL5 and CCL20, while CCL2 was expressed in normal cells and in some of the tumor cell lines. CXCL1, CXCL2, CXCL3, CXCL10, and CXCL11 were expressed in the vast majority of the cell lines, while the expression of CXCL9 and CXCL12 was restricted to fibroblasts and few tumor cell lines. None of the analyzed cell lines expressed the chemokines CCL3, CCL4, or CCL19. Of the receptors, transcript expression of CCR1, CCR2, CCR3, CCR5, CCR7, CCXR2, and CCXR3 was not detected, and CCR6, CXCR1, and CXCR4 expression was restricted to few tumor cells. Radiation caused up- and down-regulation with respect to chemokine expressions, while for chemokine receptor expressions down-regulations were prevailing. CXCL1 and CXCL12 protein expression corresponded well with the mRNA expression. We conclude that the substantial variation in chemokine and chemokine receptor expression between SCCHN offer opportunities for the establishment of assays to test for the relevance of chemokine and chemokine receptor expression in the response of SCCHN to radiotherapy and radiochemotherapy
Abridged version of the AWMF guideline for the medical clinical diagnostics of indoor mould exposure
Heavy Neutral Lepton Search at NA62
In this paper we present the results of the search for heavy neutral lepton (HNL) production in charged kaon decays using a data sample collected with a minimum bias trigger by the NA62 experiment at CERN in 2015. Upper limits at the â level are established on the elements and of the extended neutrino mixing matrix for HNL masses in the range 170â448Â and 250â376Â , respectively